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Database content
Current database content for version 2025.4 released 16 September 2025.
| Target Class | Number of human targets‡ |
|---|---|
| 7TM receptors | 400 |
| G protein-coupled receptors including orphans | 396 |
| Orphan G protein-coupled receptors* | 41 |
| Other 7TM proteins | 4 |
| Nuclear hormone receptors | 48 |
| Catalytic receptors | 253 |
| Ligand-gated ion channels | 81 |
| Voltage-gated ion channels | 144 |
| Other ion channels | 55 |
| Enzymes | 1320 |
| Transporters | 555 |
| Other protein targets | 256 |
| Total number of targets | 3112 |
| Chemical Class | Number of ligands |
|---|---|
| Synthetic organics | 9516 |
| Metabolites | 513 |
| Endogenous peptides | 826 |
| Other peptides including synthetic peptides | 1580 |
| Natural Products | 533 |
| Antibodies | 460 |
| Inorganics | 39 |
| Approved drugs | 2139 |
| Withdrawn drugs | 117 |
| Drugs with INNs | 3802 |
| Labelled ligands | 655 |
| Total number of ligands | 13511 |
| Category | Count in database |
|---|---|
| Total curated interactions | 24220 |
| Total quantitative interactions | 21981 |
| Number of unique target-ligand pairs | 19932 |
| Number of curated binding constants | 21981 |
| Number of binding constants from large-scale screens | 31207 |
| Number of references | 48507 |
| Human targets with curated interactions | 2050 |
| Human targets with quantitative interactions | 1791 |
| Human targets with quantitative interactions with CIDs | 1616 |
| Human targets of approved drugs | 769 |
| Human primary targets of approved drugs | 356 |
| Approved drugs with quantitative interactions | 1201 |
| Ligands with target interactions | 11059 |
| Ligands with quantitative interactions | 9766 |
| Ligands with CID and quantitative interactions | 8247 |
| Ligands with clinical use summary | 4137 |
| Approved drugs with clincial use summary | 2138 |
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‡ Measured by the number of distinct human UniProt entries included in the database for a given target class.
* Orphans are defined as proteins having similarity to receptors but whose endogenous ligands have not yet been conclusively identified.
