IUPHAR/BPS Guide to PHARMACOLOGY (GtP) web service output descriptions #################################################### targets https://www.guidetopharmacology.org/services/targets/ #################################################### targetId The GtP target identifier name The GtP target name, usually the IUPHAR recommended name or a provisional name (for information on target nomenclature see the online help documentation) abbreviation A commonly used abbreviation of the target name systemicName A systematic name associated with the target familyIds The GtP family identifier subunitIds The identifiers of any subunits that make up a multimeric protein complexIds The identifiers of any complexes that target is part of ############################################################ families https://www.guidetopharmacology.org/services/targets/families ############################################################ familyId The GtP family identifier name The GtP family name, usually the IUPHAR recommended name or a provisional name (for information on target nomenclature see the online help documentation) targetIds The identifiers of any targets that make up the family parentFamilyIds The identifier of any parent families subFamilyIds The identifiers of any sub-families ####################################################################### subunits https://www.guidetopharmacology.org/services/targets/[targetId]/subunits ####################################################################### targetId The GtP target identifier name The GtP target name, usually the IUPHAR recommended name or a provisional name (for information on target nomenclature see the online help documentation) abbreviation A commonly used abbreviation of the target name systemicName A systematic name associated with the target type Subunit type familyIds The GtP family identifiers subunitIds The identifiers of any subunits that make up a multimeric protein complexIds The identifiers of any complexes that target is part of subunitType ##################################################################################### geneProteinInformation https://www.guidetopharmacology.org/services/targets/[targetId]/geneProteinInformation ##################################################################################### targetId The GtP target identifier species Species name geneSymbol Gene symbol geneName Gene name officialGeneId Gene ID (Human: HGNC; Mouse: MGI;Rat: RGD) genomicLocation Chromosomal location aminoAcids Number of amino acids transmembraneDomains Number of TM Domains poreLoops Number of pore loops refs List of references ############################################################################ databaseLinks https://www.guidetopharmacology.org/services/targets/[targetId]/databaseLinks ############################################################################ accession External database accession/identifier database External database name url URL to accession/identifier species Species ########################################################################## interactions e.g. https://www.guidetopharmacology.org/services/ligands/5933/interactions ########################################################################## interactionId The GtP interaction identifier targetId The GtP target identifier ligandAsTargetId The identifier of the ligand which in this case is the target of the interaction targetSpecies The name of the target species primaryTarget Boolean; true if the target can be considered the primary target of the ligand targetBindingSite Target binding site ligandId The GtP ligand identifier ligandContext If the ligand is context-dependent e.g. intracellular, this is indicated endogenous Boolean; true if the ligand is endogenous in the target organism under study type Type of interaction action Ligand action (in context of interaction) actionComment Further details or qualifiers for the ligand action at the target selectivity Indicates if the ligand/compound is selective for the target (Selective), Non-Selective or Family-Selective (refers to compounds that distinguish a family of targets from any other group of targets). Not Determined indicates either insufficient data to identify selectivity or that this has not been examined. concentrationRange The micromolar concentration range of ligand used in the study (primarily given when affinity data are not available) affinity Affinity value(s) - negative logarithm to base 10 value (can be a range) affinityType The negative logarithm to base 10 of the experimental parameter measured originalAffinity Activity value recorded in the study (can be a range) originalAffinityType The experimental parameter measured in the study e.g. IC50 originalAffinityRelation A qualifier for the activity value, e.g. >, <, = assayDescription Further details captured about the assay assayConditions Assay conditions useDependent Boolean; voltageDependent Boolean; is interaction voltage dependent voltage Affinity voltage (can be a range) physiologicalVoltage Affinity physiological voltage conciseView Is this interaction display in the concise sumary view on the website refs List of references ################################################### ligands https://www.guidetopharmacology.org/services/ligands ################################################### ligandId The GtoPdb Ligand Identifier name GtoPdb Ligand Name abbreviation GtoPdb Ligand Abbreviation inn The International Non-proprietary Name assigned by the WHO type The type of chemical species (Peptides) The species which endogenously express a particular peptide ligand sequence radioactive Ligand has been labelled with radioactive isotope labelled The ligand has been labelled with a chemical group such as a fluorscent tag or unstable isotope approved The drug is or has in the past been approved for human clinical use by a regulatory agency withdrawn The drug is no longer approved for its original clinical use in one or more countries whoEssential Ligand included in WHO Essential Medicines list immuno Ligand tagged in Guide to Immunopharmacology (relevant to immunopharmacology) malaria Ligand is tagged in Guide to Malaria Pharmaoclogy (antimalarial) antibacterial Ligand is tagged as antibacterial approvalSource Regulatory agency (and year) that approved the drug subunitIds The GtP ligand subunit identifiers (array) complexIds The GtP ligand complex identifiers (array) prodrugIds The GtP ligand pro-drug identifiers (array) activeDrugIds The GtP ligand active drug identifiers (array) ############################################################ ligands families https://www.guidetopharmacology.org/services/ligands/families ############################################################ familyId The GtP ligand family identifier name Ligand family name ligandIds Ligand IDs in family parentFamilyIds Parent family IDs subFamilyIds Sub-family IDs ############################################################ diseases https://www.guidetopharmacology.org/services/diseases ############################################################ diseaseId GtPdb Disease identifer name Disease name description Disease description synonyms Disease synonyms (array) name Synonym name refs Reference ID for synonym (array) databaseLinks Array of external database links for the disease accession External accession ID database External database name url URL to external database species Species ############################################################ diseaseTargets Array of targets associated with the disease https://dev.guidetopharmacology.org/services/diseases/232/diseaseTargets ############################################################ targetId GtoPdb Target (Protein) ID disease Disease Information diseaseId GtPdb Disease identifer name Disease name description Disease description synonyms Disease synonyms (array) name Synonym name refs Reference ID for synonym (array) databaseLinks Array of external database links for the disease accession External accession ID database External database name url URL to external database species Species role Role of target in disease drugs - sideEffects - use - pathoComments Pathophysiology comments immunoComments Immunopharmacology comments refs Reference ID for disease-target association (array) ligandTargetInteractions Array of ligand that interact with the target ############################################################ diseaseLigand https://www.guidetopharmacology.org/services/diseases/1184/diseaseLigands ############################################################ ligandId disease Disease Information diseaseId GtPdb Disease identifer name Disease name description Disease description synonyms Disease synonyms (array) name Synonym name refs Reference ID for synonym (array) databaseLinks Array of external database links for the disease accession External accession ID database External database name url URL to external database species Species approved The drug is or has in the past been approved for human clinical use by a regulatory agency immuno Ligand tagged in Guide to Immunopharmacology (relevant to immunopharmacology) immunoComments Immunopharmacology comments clinicalUse Ligand clinical use comments bioactivityComments Ligabnd bioactivity comments ############################################################ references https://www.guidetopharmacology.org/services/refs/35060 ############################################################ referenceId GtopDb Reference identifier pmid PubMed ID type Type of reference (Journal, Book etc.) title Journal title year volume issue pages articleTitle Article title authors editors publisher publisherAddress pubStatus website doi url accessDate modifyDate isbn patentNumber priorityDate publicationDate assignee